TEM #11-6 (Skin-Human, X19,000)- This section shows a keratinocyte in the stratum spinosum of the epidermis. This keratinocyte is also referred to as prickle cell due to the large number of desmosomal junctions (4) which it forms with neighboring cells giving it a spiked appearance. Keratin filaments grouped as tonofibrils (3) may be seen coursing through the cytoplasm and abutting the desmosomal junctions. The dark staining bodies (2) in the cytoplasm are melanin granules.