HISTOLOGIC LOOK-ALIKES

Lymphocyte vs Monocyte

Lymphocyte-

• 1. Round, dark nucleus
• 2. Smaller cell (10-12u)
• 3. Less cytoplasm

Monocyte-

• 1. Indented, lighter-staining, flocculent nucleus
• 2. Larger cell (12-15u)
• 3. More cytoplasm

Pigment granules (melanosomes) vs Eosinophil granules

Pigment granules-

• 1. In formative stages each granule has several very electron-dense, elongated lamellae enclosed by a common membrane
• 2. Usually spherical

Eosinophil granules-

• 1. Typical granule has an electron-dense central band
• 2. Oval shaped